An extensive review of the medical literature on COVID-19 was performed, mainly focusing on the critical care of pediatric patients, considering expert opinions and recent reports related to this new disease. Experts from a large Brazilian public university analyzed all recently published material to produce a report aiming tostandardize the care of critically ill children and adolescents. Available in English. … Read More →

The world is fighting the COVID-19 outbreak and health workers, including inflammatory bowel diseases specialists, have been challenged to address the specific clinical issues of their patients. We hereby summarize the current literature in the management of inflammatory bowel disease (IBD) patients during the COVID-19 pandemic era that support the rearrangement of our IBD unit and the clinical advice provided to our patients. Available in English. … Read More →

A 56-year-old male patient with chronic bronchitis reported worsening of his usual dyspnea for one week prior to hospital admission, evolving to fever, productive cough, and non-massive hemoptysis, as well as a progressive need for oxygen supplementation, in the last 24h. … Read More →

We are living the most important pandemic in recent world history, caused by a novel coronavirus (SARS-CoV-2), with a significant impact on the economy, public health, and mental health of the entire society. São Paulo is the epicenter of the epidemic in Brazil. Brazilian university hospitals – centers for professional training and qualification, as well as knowledge production – have a major role in combating this epidemic. Available in English. … Read More →

Neste relatório, associamos dados da rede de fluxos rodoviários e da demografia das microrregiões paulistas com os casos confirmados de COVID-19 atualizados em 04/04/2020 para gerar informações estratégicas sobre a propagação geográfica da pandemia de SARS-CoV-2 no Estado de São Paulo. Disponível em português. … Read More →

When approaching patients with COVID-19, cardiologists should be alert to new clinical manifestations, such as arrhythmias, left ventricular dysfunction and systemic embolism, which might be related to that condition, since there is much that is still unknown about it. … Read More →

O enfrentamento da pandemia do novo coronavírus faz parte das funções essenciais da Saúde Pública por meio de ações voltadas para a população ou para grupos com maior risco de contaminação, como os profissionais de saúde. No entanto, outras atividades de trabalho podem ter um papel relevante na disseminação do vírus e, portanto, a análise de como se processam é determinante para a prevenção do adoecimento. Disponível em português. … Read More →

Attention has been focused on the exponential increase in infections, but this phenomenon – and its consequences – are certainly not limited to medical disease. Although the effects of the coronavirus on mental health have not yet been studied systematically, I would like to make a few relevant points about the mental health of the population during the ongoing pandemic. … Read More →

Our study shows that there are sixteen intervention studies in progress about COVID-19 in Brazil (CONEP registry), however, only six are available in the protocol registry databases. Brazilian open access research protocols investigated interventions with: hydroxychloroquine associated with azithromycin or monotherapy; chloroquine; dexamethasone; mesenchymal stem cells. Five studies (83%) are open and include patients with suspected or confirmed COVID-19 diagnosis. Three studies are multicenter and all include clinically relevant outcomes. Available in Portuguese. … Read More →

The recognition of imaging patterns based on the time since coronavirus infection is critical not only to understanding the pathophysiology and natural history of the infection but also to predicting patient progression and the development of complications. … Read More →

The number of confirmed cases, as April 11, surpassed 1,700,000, but this figure does not reflect the real prevalence of COVID-19 in the population, as in many countries tests are almost exclusively performed in people with symptoms, particularly severe cases. Available in Portuguese. … Read More →

The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to the host-cell infection. We perform comparative genomic analysis of 70 ACE2 placental mammal orthologues to identify variations and contribute to the understanding of evolutionary dynamics behind this successful adaptation to infect humans. … Read More →

This paper shows a technique for the detection of regularities in the complete genome of Coronavirus 2. For this, the concept of intervals in the RNA chain and their comparison within the known sequence is used. The Maximum Regularity Index was applied. The results show that areas of high regularity are identified that coincide with ORF10, Gene N, nucleocapsid phosphoprotein and others. The detection of regularities can enhance the creation of biochemical or genetic techniques to deactivate certain functions of Coronavirus 2 or control its effects. … Read More →